Protective effects of Selenium and/or Melatonin against Cadmium Chloride induced Chromosomal aberrations in Swiss Albino mice Mus musculus BALB/c

Abstract

The present study was aimed to investigate the protective role of selenium and melatonin with concentration (0.2 mg /kg b.wt./day) for selenium and (2.5 mg/kg b. wt./day) for melatonin. The doses were administered for five weeks five day per week against the genotoxic effect of orally given Cadmium chloride (1mg/kg b.wt. /day) to male albino mice for five weeks (five day per week). Thirty five male albino mice were divided into seven groups; each group contained five mice. Chromosomal studies in bone marrow cells were used as parameters in this evaluation. It was observed that the administration of Cadmium chloride generally produced more chromosomal aberrations such as (gap, break, ring, dicentric, centric fusion, end to end association, aneuploidy and polyploidy) compared with control. Chromosomal aberrations were reduced in treatment with the antioxidants (Selenium, melatonin) and their combinations .Finally, it was concluded that selenium and melatonin can serve as possible anti-genotoxic agent against the clastogenic effect of Cadmium chloride.