Abstract
The present study aimed to investigate the protective effects of salidroside on chronic heart failure (CHF) in rats and to explore the underlying mechanisms. One hundred SD rats were randomly divided into sham-operated, model, and low-, medium- and high-dose salidroside groups. The CHF model was established in later 4 groups. The later 3 groups were intragastrically administrated with 6, 12 and 24 mg/kg salidroside, respectively, once a day, for continuous 4 weeks. Finally, the serum levels of brain natriuretic peptide (BNP) and interleukin 6 (IL-6), cardiac function indexes, and expression levels of myocardial cysteinyl aspartate-specific proteinase (Caspase)-3, Caspase-9, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein were determined. Results showed that, after treatment, compared with model group, in high-dose salidroside group the heart function indexes were significantly improved (P < 0.05), the serum levels of BNP and IL-6 were significantly decreased (P < 0.05), the expression levels of myocardial Caspase-3, Caspase-9 and MMP-1 protein were significantly decreased (P < 0.05), and the expression level of TIMP-1 protein was significantly increased (P < 0.05). In conclusion, salidroside has obvious protective effects on CHF in rats. The mechanisms may be related to its regulation of cardiomyocyte apoptosis and ventricular remodelingregulation related protein expressions.
Highlights
Chronic heart failure (CHF) is a pathophysiological syndrome characterized by pulmonary circulation and/ or systemic circulation congestion due to heart pumping dysfunction, decreased cardiac output or decreased tissue perfusion in the case of normal venous return (Al-Mohammad, Mant, 2011)
After establishment of CHF model, the rats in model group presented nose and lip cyanosis, pallor of extremities, rough color and yellowing, abdominal hair shedding, lags in response, reduced feed consumption, slow action and other CHF symptoms, which were gradually aggravated with time prolonging
Studies (Zheng et al, 2017; Sun et al, 2018) have confirmed that, salidroside can inhibit the apoptosis of vascular endothelial cells, reduce the expression of vascular endothelial growth factor in atherosclerotic plaques, and inhibit the angiogenesis, thereby blocking the formation of atherosclerosis
Summary
Chronic heart failure (CHF) is a pathophysiological syndrome characterized by pulmonary circulation and/ or systemic circulation congestion due to heart pumping dysfunction, decreased cardiac output or decreased tissue perfusion in the case of normal venous return (Al-Mohammad, Mant, 2011). With the deepening of population aging and rapid increasing of primary diseases such as hypertension, coronary heart disease, diabetes and hyperlipidemia, the incidence of CHF is obviously rising (Cleland et al, 2016). The active substances of many natural medicines have the effects of improving heart function and resisting myocardial ischemia (Yin et al, 2008; Yin et al, 2009). Salidroside is one of the main effective components of Rhodiola rosea L. It has the pharmacological effects in resisting hypoxia, promoting hematopoietic function, improving microcirculation, inhibiting oxidative stress and regulating immune (Zhang et al, 2009; Zhang et al, 2013). Salidroside is widely used in prevention and treatment of coronary heart disease, hypertension, cerebrovascular disease, climacteric
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