Abstract
In this study, it was aimed to investigate the protective effect of Resveratrol, which has a strong antioxidant effect on kidney tissues of rats experimentally induced with carbon tetrachloride with nephrotoxicity, by kidney function tests and histopathology. For this purpose, 32 male Wistar Albino rats were used. The subjects were randomly selected, 1st group control, 2nd group CCl4, 3rd group Resveratrol. The 4th group was divided into 4 groups as CCl4 + Resveratrol. At the end of the experiment, animals were sacrificed under anesthesia and kidney samples were taken in 10% formalin solution for histopathological analysis. In the histopathological examination, it was found that the rats in the control and Resveratrol groups had normal kidney histological structure. In CCI4 group, severe hydropic degeneration in tubules epithelium, mild coagulation necrosis in tubules epithelium and severe hyperemia in the vessels were observed. When kidney tissues of rats were examined in CCI4 + Resveratrol group, mild hydropic degeneration in tubules epithelium and mild hyperemia in vessels were observed. When the kidney tissues of the rats in the Resveratrol group were examined, it was observed that they had a normal histological appearance. As a result, it was determined that Resveratrol has a protective effect on kidney damage caused by CCI4.
Highlights
Carbon tetrachloride (CCl4) is a fast evaporating, colorless, non-flammable and fragrant chemical
It was aimed to investigate the protective effect of Resveratrol, which has a strong antioxidant effect on kidney tissues of rats experimentally induced with carbon tetrachloride with nephrotoxicity, by kidney function tests and histopathology
Kidney function tests When the groups were compared in terms of kidney function tests, it was determined that urea, creatine and BUN levels were normal in the control group, but these values were increased in the CCl4 group
Summary
Carbon tetrachloride (CCl4) is a fast evaporating, colorless, non-flammable and fragrant chemical. If the CCl4 level in the body exceeds certain levels, an increase in oxidative stress and serious damage to components such as protein, lipid and nucleic acid in the cell occurs [5]. It has been determined as a result of studies that CCl4 causes organ toxicities in tissues such as liver [6], heart [7], brain [8] and kidney [9].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
