Abstract
Objective: The aim of this study was to determine the effects of resveratrol on ischemia- reperfusion (I/R) injury in the rats sciatic nerve. Methods: We used 18 Wistar rats anesthetized with ketamine (50 mg/kg-im). In the sham group, we only performed the surgery and not administer any medication. In the ischemia group, we generated I/R injury in 5 minute intervals with medical treatment of saline only. In the resveratrol group, we brought about the same I/R injury but gave resveratrol before the surgery by per oral. After sacrifice, we studied blood and nerve tissue samples. We evaluated the damage with malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC), both in tissue and blood. Results: Evaluation of serum levels of antioxidant markers and tissue samples demonstrated statistically significant effects of resveratrol in ischemia-reperfusion injury. Conclusion: This study revealed the antioxidant effect of resveratrol as an inhibitor of lipid peroxidation.
Highlights
The squamous cell carcinoma of the breast is an uncommon neoplasm, which comprises 0.04-0.1% of all breast carcinomas [1]
We report a patient with primary squamous cell carcinoma of the breast in order to discuss the general aproaches to this disease and treatment modalities
Physical examination revealed a gross mass, 9x8 cm in diameter, located on the lateral border of left breast
Summary
The squamous cell carcinoma of the breast is an uncommon neoplasm, which comprises 0.04-0.1% of all breast carcinomas [1]. The data about its epidemiology, clinical presentation, radiologic images, biological behaivour and outcomes are limited and based on single reports. They are rapidly progressing tumors with resistance to the treatment and poor prognosis. We report a patient with primary squamous cell carcinoma of the breast in order to discuss the general aproaches to this disease and treatment modalities
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