Abstract
AbstractThe in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical‐induced damage of biological membranes and the protective effect of resveratrol (3,5,4′‐trihydroxy‐trans‐stilbene, 1) and its analogues, i. e., 4‐hydroxy‐trans‐stilbene (2), 3, 5‐dihydroxytrans‐stilbene (3), 3,4‐dihydroxy‐trans‐stilbene (4), 4,4′‐dihydroxy‐trans‐stilbene (5) and 2, 4, 4′‐trihydroxy‐trans‐stilbene (6). The hemolysis of RBCs was induced by a water‐soluble free radical initiator 2, 2′‐azobis (2‐amidinopropane hydrochloride) (AAPH). It was found that addition of AAPH at 37 °C to the suspension of RBCs caused fast hemolysis after a short period of inhibition period, and addition of 1–6 significantly suppressed the hemolysis. Compound 4 which bears an ortho‐dihydroxyl functionality showed much more effective anti‐hemolysis activity than that of resveratrol and the other analogues.
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