Abstract
Ranolazine is a drug used in refractory chronic stable angina. In this study, it was aimed to evaluate the protective effect of ranolazine in a testis torsion model in light of objective biochemical and pathological data. A total of 24 pre-pubertal male Wistar albino rats were separated into three groups of 8 as the sham group, control group and ranolazine group. Testis torsion was applied for 3hr to all the rats in Group Control and Group Ranolazine. In Group Control, 0.9% NaCl was applied 1hr after the torsion. In Group Ranolazine, ranolazine 30mg/kg was dissolved in a 0.9% NaCl solution and was administered intraperitoneally 1hr after torsion. Histopathological evaluation was made using the Cosentino score. As a result of the objective biochemical and pathological criteria used in this study, this protective effect of ranolazine was observed in testis torsion. The results obtained in this study may suggest that ranolazine is a drug that could be applied after detorsion to patients diagnosed with torsion.
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