Abstract
Aim: Methylglyoxal (MG), a dicarbonyl compound, is found in all cells under normal or pathological conditions as a product of cellular metabolism. Quercetin is known to have antioxidant, anti-apoptotic and neuroprotective effects. The aim of the present study is to investigate whether quercetin reduces methylglyoxal-induced toxicity in neuron-like SH-SY5Y cells. 
 Materials and Methods: To determine the effective toxic dose of MG, different doses (0-1000 µM) of MG were added to the culture medium and cell viability was determined by MTT test after 24 hours of incubation. Then, quercetin (0.1 and 1 µM), was given to the culture medium together with MG, and cell viability, cell morphology, apoptotic cell death, formation of reactive oxygen species (ROS), total antioxidant capacity (TAC) and total oxidant stress (TOS) were evaluated. 
 Results: MG increased cell death in SH-SY5Y cells depending on the concentration. MG caused significant deterioration in the morphological features of the cells, increased apoptotic cell death and formation of reactive oxygen species. Also, total oxidant stress levels was found to be higher in the MG-added cells compared to the control (p
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