Abstract
Among flavonoids, chalcones have been identified as interesting compounds having antioxidant, antimutagenic and antitumour properties. In this study we have evaluated the clastogenicity of plicatin B on human lymphocytes (whole blood and isolated lymphocytes) and its anticlastogenic activity, in the same cellular systems, using mitomycin C (MMC), radio-mimetic bleomycin (BL) and hydrogen peroxide (H 2O 2) as reference clastogens. Plicatin B per se resulted cytotoxic at high dose but non-clastogenic. The clastogenic effects induced by MMC and BL were significantly reduced (−33%) whereas with H 2O 2 the protective effect of plicatin B was observed (−62%) only at the greater H 2O 2 dose. The anticlastogen effects of plicatin B were effective when the chalcone was introduced in the culture,1 h before the reference clastogens.
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