Abstract
BackgroundDiabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Therefore, the present study was conducted to evaluate the protective effect of peel extracts of Irvingia wombolu against diabetes complications.MethodsDiabetes was induced by intravenous administration of streptozotocin (STZ) (50 mg/kg) through the right jugular vein on rats and animals with blood glucose values of at least 250 mg/dl received orally aqueous extract of peel (AEP), hydroethanolic extract of peel (HEP), tolbutamide and DMSO 10%. Their effects on the concentration of blood glucose, total cholesterol, HDL-C, LDL-C, triglycerides, malondialdehyde (MDA) and activities of catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic and normal rats were investigated using standard methods.ResultsTwenty-one days of treatment with AEP and HEP at a dose of 400 mg/kg significantly (P < 0,05) reduced the fasting blood glucose to a point of reaching normal value. The antihyperlipidemic assessment of extracts revealed a significant (P < 0,05) decrease in total cholesterol, triglycerides, LDL levels, and a significant (P < 0,05) increase in HDL level in the plasma of treated diabetic rats. Furthermore, plasma biomarkers of liver and kidney dysfunction were significantly reduced in treated diabetic rats. We also observed increased activities of catalase, SOD, and reduced glutathione in diabetic treated rats.ConclusionThe present findings suggest that AEP and HEP have a protective effect on liver, kidney, and heart in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.
Highlights
Diabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities
They showed a protective effect in the induction of insulin resistance with a high-fat high-fructose (HFHF) diet reported by a lower increase in fasting blood glucose and triglycerides and post-prandial glycemic peak [7]
It was hypothesized that peel extracts of Irvingia wombolu may reduce blood sugar and lipids levels, and has the ability to protect against diabetes related complications like renal, hepatic, and cardiac failure
Summary
Diabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Permanent hyperglycemia is a leading cause of diabetes mellitus (DM) which is a chronic metabolic disorder that can cause damages in all systems in the body if not treated It is a major global public health problem with an escalating incidence and prevalence in (2020) 6:71 modes of action and their effect on insulin [4]. We evaluated the activities of peel extracts of Irvingia wombolu which in previous studies have shown its richness in bioactive compounds which can inhibit free radicals and lipid peroxidation [6] They showed a protective effect in the induction of insulin resistance with a high-fat high-fructose (HFHF) diet reported by a lower increase in fasting blood glucose and triglycerides and post-prandial glycemic peak [7]. Peel extracts of Irvingia wombolu were tested in the rat model of type I diabetes induced by streptozotocin
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
