Abstract
Polyhydroxylated, water soluble, fullerenol C60(OH)24 nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity. The goal of this work was to investigate the potential protective effects of orally applied FNP on rats after a single dose of doxorubicin (DOX) (8 mg/kg (i.p.)) 6 h after the last application of FNP. After the last drug administration, the rats were sacrificed, and the blood and tissues were taken for the analysis. Biochemical and pathological results obtained in this study indicate that fullerenol (FNP), in H2O:DMSO (80:20, w/w) solution given orally in final doses of 10, 14.4, and 21.2 mg/kg three days successively, has the protective (hepatoprotective and nephroprotective) effect against doxorubicin-induced cytotoxicity via its antioxidant properties.
Highlights
Polyhydroxylated, water soluble, fullerenol C60(OH)24 nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity
For all groups measured in comparison to the untreated control group (I), the coefficient is not significantly different except for the FNP and for the treated group (IV) (Figure 2)
Animals from the group protected by a three-day oral application of FNP (V) and from operating control group had ALT levels comparable to the control group that received saline only (I) (Figure 3)
Summary
Polyhydroxylated, water soluble, fullerenol C60(OH) nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity. The mechanism of DOX-induced cardiotoxicity includes expression of nitric oxid syntheses, changes in calcium homeostasis and alteration of molecular signalling [5,6]. All these interactions lead to cell death. The clinical usefulness of DOX is restricted, due to several acute and chronic side effects, especially a dose-dependent myocardial injury, which can cause congestive heart failure. The size evolution of fullerenol clusters is dynamic and is sensitive to changes in environmental conditions like pH and temperature [13]
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