Abstract
Magnesium (Mg) deficiency was found to increase noise-induced hearing loss in laboratory animals. This paper reports both prophylactic and therapeutic effects of Mg on the acoustic trauma produced by a high-level impulse noise series (Lpeak 167 dB, 38 min, 1/s). Hearing loss was tested by auditory brainstem response audiometry at frequencies between 0.5 and 32 kHz. Permanent hearing threshold shifts (PTS) were measured 1 week after the exposure. For the prophylaxis experiments, anesthetized guinea pigs with either a physiologically high or low Mg status, produced by different diets, were used. For the therapy experiments, animals with the low Mg status received (immediately after exposure) either Mg injections combined with a Mg-rich diet or saline as a placebo. Total Mg concentrations of perilymph, cerebrospinal fluid, and plasma were analyzed to test the Mg status of the animals. The PTS was found to be significantly lower in the high-Mg group than in the low-Mg group. This also applies to the PTS found between the therapy and the placebo groups. There was a good correlation between the PTS and the perilymphatic Mg. The intracochlear Mg level seems to play an important role in the acoustic trauma. [Supported by German Defence Ministry.]
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