Protective effects of heat shock proteins on ischemia/reperfusion organ injury in ischemic postconditioning

Abstract

Background Ischemia postconditioning (IPo) is an effictive and practical way to reduce ischemia/reperfusion organ injury (I/RI).It is becoming the hot spot of research recently.Heat shock proteins (HSP) is the biological marker of stress response and endogenous protective proteins,which are involved in the process of organ reperfusion injury. Objective To summarize the study progress of ischemic postconditioning and HSP in I/RI and provide new ideas for further study. Content National and international studies have shown that IPo can reduce ischemia/reperfusion organ injury and it is being applied to the clinical settings.Heat shock proteins can attenuate oxidative stress responses and inflammatory reaction,reduce apoptosis,and protect the integrity of cytoskeleton in I/RI. Trend The protective mechanism of IPo should be further explored to provide the theoretical basis for its clinical application. Key words: Ischemia postconditioning; Heat shock protein; Ischemia/reperfusion injury