Abstract
BackgroundObesity is a public health problem characterized by increased fat accumulation in different tissues. Obesity is directly linked to breathing problems and medical complications with lung, including obstructive sleep apnea syndrome, obesity hypoventilation syndrome, chronic obstructive pulmonary disease, asthma….In the present work, we aimed to investigate the effect of high fat diet (HFD) on lung lipotoxicity, oxidative stress, fatty acid composition and proportions in lung and implication in asthma development. The likely protection provided by grape seed extract (GSSE) was also investigated.MethodsIn order to assess HFD effect on lung and GSSE protection we used a rat model. We analyzed the lipid plasma profile, lung peroxidation and antioxidant activities (SOD, CAT and POD). We also analyzed transition metals (Ca2+, Mg2+, Zn2+ and iron) and lung free fatty acids using gas chromatography coupled to mass spectrometry (GC-MS).ResultsHFD induced lipid profile imbalance increasing cholesterol and VLDL-C. HFD also induced an oxidative stress assessed by elevated MDA level and the drop of antioxidant activities such as SOD, CAT and POD. Moreover, HFD induced mineral disturbances by decreasing magnesium level and increasing Calcium and iron levels. HFD induced also disturbances in lung fatty acid composition by increasing oleic, stearic and arachidonic acids. Interestingly, GSSE alleviated all these deleterious effects of HFD treatment.ConclusionAs a whole, GSSE had a significant preventive effect against HFD-induced obesity, and hence may be used as an anti-obesity agent, and a benefic agent with potential applications against damages in lung tissue.
Highlights
Obesity is a public health problem characterized by increased fat accumulation in different tissues
Obesity is a chronic disease characterized by excessive accumulation and storage of body fat that is harmful to individuals
The aim of the present study is to investigate on HFDinduced lung toxicity and oxidative stress and to determine physiological connections between high fat diet (HFD) and asthma
Summary
Obesity is a public health problem characterized by increased fat accumulation in different tissues. Obesity is directly linked to breathing problems and medical complications with lung, including obstructive sleep apnea syndrome, obesity hypoventilation syndrome, chronic obstructive pulmonary disease, asthma....In the present work, we aimed to investigate the effect of high fat diet (HFD) on lung lipotoxicity, oxidative stress, fatty acid composition and proportions in lung and implication in asthma development. Obesity is a chronic disease characterized by excessive accumulation and storage of body fat that is harmful to individuals. Obesity is a multifactorial disease which depend on the interaction of multiple factors including genotype, environment, lifestyle and the unbalance between diet and caloric requirements. The increased morbidity and mortality associated with obesity is reflected by numerous chronic diseases, including. Obesity has been linked to lung problems and respiratory symptoms.
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