Abstract
Abstract The inhibitory effects of ginger essential oil (GEO) on chemically-induced cutaneous inflammation were investigated. Three kind of experimental murine models, such as xylene-induced ear edema model, carrageenan-induced paw edema model and 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) model were exploited to evaluate the anti-inflammatory effect of GEO. Results showed that GEO lowered the ear swelling rate induced by xylene and decreased paw edema rate induced by carrageenan of mice with cutaneous inflammation significantly. Treatment with GEO significantly inhibited DNFB-induced ear swelling degree and rate, and alleviated the inflammatory symptoms of ear skin lesions of ACD model mice markedly. Treatment with GEO decreased the gene expression of the inflammatory cytokines of auricular tissues such as TLR-2, TLR-4, TNF-α, IFN-γ, IL-1β, IL-8, and increased the gene expression of cytokine IL-4 significantly. In conclusion, GEO has anti-inflammatory and protective effect on chemically-induced cutaneous inflammation.
Highlights
Ginger, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), is the traditional kind of food materials worldwide, and it has been reported that its extracts presented some pharmacological activities
The pathogenesis of dermatitis is delayed-type hypersensitivity (DTH) reaction caused by repeated exposure to the haptens, such as 2,4-dinitrofluorobenzene (DNFB)
Penna et al (2003) reported that crude hydroalcoholic extract of Zingiber officinale had antiedematogenic activity and was able to reduce rat paw and skin edema induced by carrageenan and serotonin
Summary
The rhizome of Zingiber officinale Roscoe (Zingiberaceae), is the traditional kind of food materials worldwide, and it has been reported that its extracts presented some pharmacological activities. Topical application of DNFB to the skin induced inflammatory responses, known as allergic contact dermatitis (ACD), by attracting inflammatory cells, increasing level of pro-inflammatory cytokines (Wang et al, 2015). Penna et al (2003) reported that crude hydroalcoholic extract of Zingiber officinale had antiedematogenic activity and was able to reduce rat paw and skin edema induced by carrageenan and serotonin. Little information is available about the effects of GEO on skin inflammation such as ACD in vivo studies, especially concerning inflammatory cytokines induced by DNFB challenge. The present study would explore the anti‐inflammatory effects of GEO prepared by supercritical carbon dioxide extraction method on skin inflammation. The present study would provide the experimental basis for application of GEO as the candidate of functional component for ameliorating skin inflammation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
