Abstract
ABSTRACTEthanol extract from Astragalus glycyphylloides was investigated for possible protective effect on carbon tetrachloride (CCl4)-induced cytotoxicity (model of metabolic bioactivation) (86 μmol/L) in isolated rat hepatocytes, a well-controlled biological model system in vitro with high metabolizing capacity. Hepatocytes isolated by two-step collagenase perfusion were treated with 10 μg/mL and 100 μg/mL of the extract and with silymarin—7 μg/mL and 70 μg/mL. In this model, the extract had statistically significant cytoprotective and antioxidant activity, near to those of silymarin. These data are supported by reports about the protective effects of saponin isolated from Astragalus membranaceus and Astragalus sieversianus on hepatotoxicity induced by CCl4 and Paracetamol in mice.
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