Abstract
To study the protective effect of collagen peptide on human periodontal ligament fibroblasts (hPDLFs) induced by lipopolysaccharide and its possible mechanism. Lipopoly-saccharide was used as a pathogenic factor to stimulate hPDLFs. Then, interleukin-8 and tumor necrosis factor-α in the supernatant were quantified, and Toll-like receptor 4 expression and the activation of nuclear factor-κB pathway were also studied. The results showed that collagen peptide above 100 mg/L could effectively reduce the toxicity of lipopolysaccharide, and significantly reduce interleukin-8 and tumor necrosis factor-α produced by lipopolysaccharide. Suggesting that collagen peptide can provide effecitve and safe solution to oral cavity repair.
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