Abstract
The protective effect of zinc selenium tea against metabolic syndrome (MetS) was tested by using a high-sucrose-high-fat diet (HSHFD)-induced MetS model. Fifty Sprague–Dawley rats were randomly divided into five groups: normal diet (C-group), HSHFD (CH-group), HSHFD + green tea (0.24 g/kg/day) (TH-group), HSHFD + low-dose zinc selenium organic tea (0.24 g/kg/day) (ZTHL-group), and HSHFD + high-dose zinc selenium organic tea (1.20 g/kg/day) (ZTHH-group). After 8 weeks, compared to both the C-group and CH-group, the hepatosomatic index (HI) was significantly reduced in the ZTHL-group (p < 0.05). Fasting blood glucose (FBG) levels were highest in the TH-group, followed by the CH-group, then the ZTHL-group, then the ZTHH-group, and finally the C-group. Compared with the CH-group, the serum total cholesterol (TC) and low density lipid-cholesterol (LDL-C) concentrations were significantly lower in the ZTHH-group (p < 0.05). Significant decreases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acids (TBA), alkaline phosphatase (ALP), and direct bilirubin (DBIL) levels were observed in ZTHL-group versus the CH-group (p < 0.05). Serum alpha-L-fucosidase (AFU) levels in the ZTHH-group were lower than in the CH-group (P < 0.01). Histopathological examination of the liver and fat biopsies illustrates that the liver cells showed a decrease in the extent of necrosis and dropsy in the ZTHL-group and ZTHH-group versus the CH-group. Zinc selenium tea showed a protection effect against hepatic damage.
Highlights
Tea, from a biological standpoint, is a mixture of a large number of bioactive compounds including catechins, flavonols, lignans, and phenolic acids
We investigated the potential beneficial influence of Chinese Fenggang zinc selenium tea on glucose and lipid metabolism disorders and liver injury
The results of this study showed that Fenggang zinc selenium tea can combat glucose and lipid metabolic disorders and improve hepatic function
Summary
From a biological standpoint, is a mixture of a large number of bioactive compounds including catechins, flavonols, lignans, and phenolic acids. Studies have indicated that tea and its constituents may have properties that help to prevent cancer, metabolic syndrome (MetS), and other disease states[1,2]. Increasing evidence suggests that green tea and its bioactive polyphenolic compounds can significantly ameliorate certain features of metabolic syndrome and help to reduce the subsequent risk of developing type 2 diabetes mellitus and cardiovascular disease (CVD)[4,5]. The tea is well known for being rich in organic zinc and selenium, in addition to containing normal levels of green tea polyphenols[6]. Several studies have shown that zinc and selenium-rich green teas have positive effects in regards to their antioxidant ability in animals. Epidemiological studies have shown that metabolic syndrome is associated with higher plasma selenium concentrations in women (odds ratio (OR) Z 1.55(1.28e1.89))[21]. We surmised that maintaining normal serum zinc and selenium level is beneficial for preventing MetS
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