Abstract
Carica papaya is one of the most popular plants around the world. Various parts of Carica papaya have been used as ingredients in traditional medicine. However, no skin photoaging-related research has been performed with Carica papaya leaf (CPL). In the present study, Carica papaya leaf was investigated for its skin anti-aging effects in UVB-irradiated normal human dermal fibroblasts (NHDFs). Carica papaya leaf significantly suppressed UVB-induced activation of mitogen-activated protein kinases (MAPKs) and activator protein-1 (AP-1) signaling by scavenging reactive oxygen species (ROS) generation. Furthermore, our results indicated that CPL prevented degradation of Type I procollagen by positively modulating transforming growth factor-β1 (TGF-β1) activity and negatively regulating matrix metalloproteinases (MMPs) expression. Thus, the synthesis of Type I procollagen, a major component of extracellular matrix (ECM) was increased. In addition, a combination of both active compounds suggests they were active compounds of CPL. Taken together, the results suggest that Carica papaya leaf is promising for further investigation and development of a cosmetic product for the treatment of various skin conditions, including photoaging.
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