Abstract
INTRODUCTION: Tamoxifen is one of the ideal drugs in treatment of breast cancer however it hasgenotoxic and cytotoxic activity on the liver via producing reactive oxygen species.AIM: To investigate the injurious effect of tamoxifen on liver of the adult female albino rats and to findout the possible protective effect of Black Seed and/or Vitamin C against this hepatic injury.METHODS: Thirty adult female albino rats were randomly divided into 5 groups;control, tamoxifen,tamoxifen + blackseed, tamoxifen +vitamin C and tamoxifen +blackseed and vitamin C treated groups.On the 22nd day after tamoxifen administrationthe rats were sacrificed; the livers wereprocessed formeasurement of MDA &SOD and for light and electron microscopic examination.RESULTS: Co-administration of black seed and/or vitamin C with tamoxifen caused significant decreasein the elevated serum GPT and GOT and the liver tissue MDA and increase in the decreased liver tissueSOD when compared with tamoxifen group. By Light microscopic examination, tamoxifen has beenfound to cause several liver changes in the form of hepatocyte degeneration and necrosis, inflammatorycell infiltration, dilated sinusoids with hypertrophy of Kupffer cells, collagen deposition and nuclearchanges as chromatin clumping and trizomy. Electron microscopic examination of tamoxifen grouprevealed nuclear changes, dilated vesicular rER, secondary lysosomes, swollen mitochondria and lipiddroplets. Administration of black seed and/or vitamin C with tamoxifen reduced the hepatic pathologicalchanges.CONCLUSION: Combination of both black seed and vitamin C might have synergistic hepato-protectiveeffect.
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