Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women.

Nicole Noren Hooten,Ngozi Ejiogu,Michele K Evans,Alan B Zonderman

doi:10.1155/2015/516783

Nicole Noren Hooten, Ngozi Ejiogu + Show 2 more

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https://doi.org/10.1155/2015/516783

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Abstract

Background. Since high sensitivity C-reactive protein (hsCRP) is predictive of cardiovascular events, it is important to examine the relationship between hsCRP and other inflammatory and oxidative stress markers linked to cardiovascular disease (CVD) etiology. Previously, we reported that hsCRP induces the oxidative stress adduct 8-oxo-7,8-dihydro-2′deoxyguanosine (8-oxodG) and that these markers are significantly associated in women. Recent data indicates that brain-derived neurotrophic factor (BDNF) may have a role in CVD. Methods and Results. We examined BDNF levels in 3 groups of women that were age- and race-matched with low (<3 mg/L), mid (>3–20 mg/L), and high (>20 mg/L) hsCRP (n = 39 per group) and found a significant association between hsCRP, BDNF, and 8-oxodG. In African American females with high hsCRP, increases in BDNF were associated with decreased serum 8-oxodG. This was not the case in white women where high hsCRP was associated with high levels of BDNF and high levels of 8-oxodG. BDNF treatment of cells reduced CRP levels and inhibited CRP-induced DNA damage. Conclusion. We discovered an important relationship between hsCRP, 8-oxodG, and BDNF in women at hsCRP levels >3 mg/L. These data suggest that BDNF may have a protective role in counteracting the inflammatory effects of hsCRP.

Highlights

Continued efforts to enhance our understanding of cardiovascular disease (CVD) in women have strengthened risk assessment, diagnosis, and treatment of this disease; CVD remains the primary cause of death of women over the age 25 [1]
We wanted to examine the relationship of CVD risk factors and oxidative stress and inflammatory markers over the full range of high sensitivity C-reactive protein (hsCRP) levels, as data from the Women’s Health Study has shown that women with high levels (≥10 mg/L) of hsCRP have a high risk and women with very high levels of hsCRP (>20 mg/L) were at the very highest risk for future cardiovascular events [20,21,22]
Compared to the low hsCRP group, brain-derived neurotrophic factor (BDNF) levels were significantly higher in the mid C-reactive protein (CRP) group (p ≤ 0.0001), but not statistically significant in the high hsCRP group

Summary

Introduction

Continued efforts to enhance our understanding of cardiovascular disease (CVD) in women have strengthened risk assessment, diagnosis, and treatment of this disease; CVD remains the primary cause of death of women over the age 25 [1]. Recent evidence suggests that levels of the CVD risk factor high sensitivity C-reactive protein (hsCRP) differ among AAs and whites and are elevated in females versus males [1, 3]. It is important to analyze the relationship of hsCRP to other CVD risk factors and inflammatory markers. Since high sensitivity C-reactive protein (hsCRP) is predictive of cardiovascular events, it is important to examine the relationship between hsCRP and other inflammatory and oxidative stress markers linked to cardiovascular disease (CVD) etiology. In African American females with high hsCRP, increases in BDNF were associated with decreased serum 8-oxodG. We discovered an important relationship between hsCRP, 8-oxodG, and BDNF in women at hsCRP levels >3 mg/L These data suggest that BDNF may have a protective role in counteracting the inflammatory effects of hsCRP

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