Abstract
Lipid peroxidation mediated by oxygen radical is one of the main mechanisms underlying secondary brain injury. Among all vitamin E compounds, α-tocopherol shows the most prominent antioxidative effects. It plays an important role in cell aging and injury. However, there has been no report regarding the effects of α-tocopherol on changes in brain tissue morphology after intracerebral hemorrhage (ICH), cerebral edema, or the expression of Bax and Bcl-2 proteins. We use SD rats to carry out the related studies; based on the atlas of SD rats, the caudate nucleus was positioned using a stereotaxic apparatus, and 50 μl autologous tail artery blood was injected to caudate nucleus in the ICH and α-tocopherol groups to establish ICH model. Rats in the sham surgery group received the same volume of saline in the caudate nucleus. Rats in the α-tocopherol group received intraperitoneal injections of α-tocopherol at 600 mg/kg every day. Rats in the ICH group and sham surgery group received the same amount of saline at the same times as those in the α-tocopherol group. We observed some interesting results: comparisons of brain tissue sections of rats from different groups showed that brain tissue damage and functional neurological deficits among rats from the α-tocopherol group were less pronounced than in the ICH group. Wet weight/ dry weight measurement showed that rats from the α-tocopherol group exhibited less cerebral edema than those in the ICH group. Rats from the α-tocopherol group showed less Bax expression and more Bcl-2 expression than those in the ICH group.
Highlights
Pathological testing showed that, in rats from the sham surgery group, the brain tissues nearest the needle track exhibited only minor damage, and there was no notable change in cell arrangement (Figure 1(I))
Large vesicular regions were observed around the hematoma, indicative of severe cerebral edema; infiltration of inflammatory cells was notable
Animal experiments have demonstrated that when intracerebral hemorrhage (ICH) occurs, edema forms, and the neurological functions of the rats are influenced to different extents
Summary
It accounts for 17.1% - 55.4% of all strokes in China [1]. This is far higher than the 6.5% - 19.6% in Western countries [2]-[4]. Common causes of ICH include hypertension, cerebral arteriosclerosis, and cerebrovascular malformation, with the former two being the leading causes [5]-[7]. ICH has become a severe cerebral complication. It occurs frequently in middle-aged and elderly patients with hypertension. Due to its acute onset and fast progression, the mortality rate of ICH has remained high, and it poses a severe threat to the health of middle-aged and elderly individuals
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
