Abstract
Aims: Organ toxicity results from the accumulation of toxic substances in the organs which ultimately culminates in failure of the organ. Allopathic medications are not very effective in organ protection. Hence, it is imperative that a natural and safer organoprotective agent should be found.
 Study Design: To assess the organoprotective effect of Aloe vera gel against STZ for renal, hepato and pancreatic toxicity in albino Wistar rats.
 Place and Duration of Study: Whole work had been completed at the Microbiology and Molecular biology labs of IMBB, The University of Lahore during 2019- 2020.
 Methodology: Organoprotective ability of different doses of ethanolic extracts of Aloe vera (A. vera) gel was evaluated against intraperitoneal induction of 55mg/kg Streptozotocin (STZ)-induced pancreatic, renal and hepatic toxicity in female albino Wistar rats by keeping metformin (100mg/kg) as a positive protective control.
 Results: Results revealed that 200 mg/kg ethanolic extracts of A. vera gel showed significant organoprotection as ALT (57.5±7.45I U/L), AST (39.8±3.45I U/L), ALP (438±103I U/L), urea (74.1±8.71mg/dl), creatinine (0.688±0.146 mg/dl), amylase (1247±75 U/L) and lipase (16.6±2.02 U/L) were significantly less than organotoxic control [ALT (103±7.23I U/L), AST (237±12.7I U/L), ALP (2092±195 U/L), Urea (153±18.6mg/dl), Creatinine (1.54±0.262 mg/dl), amylase (675±83 U/L) and lipase (12.2±1.04 U/L)], and these results were near or equal to organoprotective control [ALT (71.6±8.98I U/L), AST (121±28.1 U/L), ALP (916±103 U/L), urea (115±11.4mg/dl), creatinine (1.14±0.226 mg/dl), amylase (667±80 U/L) and lipase (16.6±2.02 U/L)]. The histopathological analysis also highlighted more organoprotection at this concentration as compared to other doses of extract.
 Conclusion: A. vera gel extract is an able organoprotective agent. This extract can be studied further for its active ingredients as a source of hepatoprotective and nephroprotective agents.
Highlights
Human beings come across thousands of chemicals in their everyday life
The aloe gel protects the liver from damage in rats by enhancing the activity of a liver enzyme associated with carcinogenic metabolism [33,34].The use of herbal plants proved to be effective in organoprotection because synthetic medications have unintended side effects or contraindications
This study investigated the organ protective role of A. vera on STZ induced organ toxicity
Summary
Human beings come across thousands of chemicals in their everyday life. Approximately, 200 to 1000 new chemicals are synthesized and released in our environment every year by the chemical industry. As toxicity is “the accumulation of injury over short or long periods of time, which renders an organism incapable of functioning within the limits of adaptation.’’[3]. Based on this definition, toxicity is mainly dependent on two factors, time and dosage. Hepatotoxicity alludes to malfunctioning of liver or it can indicate hepatic impairment which is connected with an overwhelming number of drugs or xenobiotics [6]. Examples of such drugs include allyl alcohols, acetaminophen, ethanol and cadmium chloride [7]. Instigating factor for hepatic impairment can either come from the primary compound itself, or it can come from a reactive metabolite or it can come from a bioimmunological response that involves hepatic parenchymal cells, epithelial cells of the biliary channels and/ or blood vessels of liver [9]
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