Abstract
The red maple (Acer rubrum) species is endemic to eastern North America. It has been used as a folk medicine by the indigenous people of North America to treat dermatological ailments including skin irritation and inflammation. A series of glucitol‐core containing gallotannins (GCGs) has previously been identified from red maple aerial plant parts. Also, ginnalin A (GA), a major GCG in a proprietary phenolic‐enriched red maple leaves extract (Maplifa™), showed anti‐melanogenic effects in murine melanoma B16F10 cells by down‐regulation of tyrosinase and melanogenic gene expression as well as reduction of oxidative stress. However, the dermatological protective effects of Maplifa™ and GA on keratinocytes remain unknown. Herein, we report the protective effects of Maplifa™ and GA on hydrogen peroxide (H2O2)‐induced oxidative stress in human keratinocyte HaCaT cells. H2O2 (at 200 μM) induced cell damage of HaCaT cells and reduced cell viability by 14%. Maplifa™ (at concentrations ranging from 6.25–25 μg/mL) significantly reduced H2O2‐induced cytotoxicity in HaCaT cells and increased cell viability by 25–55%, respectively, as compared to the H2O2‐treatment group. Similarly, GA (at concentrations ranging from 6.25–50 μM) significantly increased cell viability by 34–47% respectively, as compared to the H2O2‐treatment group. In summary, Maplifa™ may have skin protective effects by reducing oxidative stress in keratinocyte HaCaT cells warranting further studies to evaluate its cosmetic applications.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Published Version
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