Abstract
In this study, the effects of 3-benzoyl-7-hydroxy coumarin molecule on mineral and antioxidant enzymes were investigated in rat liver exposed to oxidative stress with aluminium chloride (AlCl3). Adult male Wistar albino rats were divided into four groups as Control, Coumarin, AlCl3, and Coumarin + AlCl3. Coumarin at the dose of 10 mg / kg and AlCl3 at the dose of 8.3 mg / kg were administered for 30 days every other day. In AlCl3 group, malondialdehyde (MDA), iron (Fe), aluminium (Al) and copper (Cu) levels increased compared to the control group, while glutathione (GSH) level, glutathione S-transferase (GST), and carboxylesterase (Ces) enzyme activity levels decreased. In Coumarin + AlCl3 group, MDA, Fe, Al and Cu levels decreased with the effect of coumarin compared to AlCl3 group, while GSH level, and GST enzyme activity levels increased. According to our results, AlCl3 generates oxidative stress in rat livers, and we believe that 3-benzoyl-7-hydroxy coumarin has an ameliorative effect on antioxidant enzyme system, Al, Fe and Cu levels.
Highlights
IntroductionPeople are exposed to Al throughout life in many ways such as through cooking utensils, drinking water, antacids, deodorants, food additives, spices, teas and dialysis processes
Aluminium (Al) is a metal commonly found in soil
We found that 3-benzoyl-7-hydroxy coumarin improves both Al, Fe and Cu concentrations in the liver, and positively affects the antioxidant system
Summary
People are exposed to Al throughout life in many ways such as through cooking utensils, drinking water, antacids, deodorants, food additives, spices, teas and dialysis processes. Al accumulates in many organs such as liver, brain, heart and lung. As a result of its toxic effects, Al causes many disorders such as anaemia, brain diseases, muscle weakness and lung problems.[1,2] In particular, in Alzheimer’s Disease, it has been suggested to play a role in the progression of the disease.[3] Liver is one of the most important organs of metabolism, regulating detoxification and secretory functions. Studies have reported that Al accumulates in liver and causes harmful effects.[4,5] Significant changes in haemato-biochemical parameters of rats and rabbits exposed to Al were detected. Al causes an increase in hepatic MDA levels and a decrease in antioxidant enzymes.[6,7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
