Abstract
On model of acute intoxication of karbofos, dichloroethane and etilenglikoly (all 256 ± 8.7 mg/ kg) at rats studied mechanisms of protective action of derivatives of tiobenzimidazole (metaprot and etomerzol) 25 and 50 mg/kg. Both preparations renewed of tolerance of physical activity, normalized activity of ASAT, ALAT, reduced levels of bilirubin, a creatinine and urea nitrogen. Impact on processes of lipid peroxidation was expressed in decrease in concentration low-new of dialdehyde and increase of levels restored of glutathione, indicators of endogenous intoxication were thus eliminated. Anti-hypoxemic, antioxidant, aktoprotektorny, energotropny, reparation effects metaprot and etomerzol are proved.
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