Abstract
Abstract This investigation was aimed to study the effect of Pinus halepensis aqueous bark extract and zinc to prevent indomethacin induced gastric ulcer in rats. Thirty female albino Wistar rats were divided into 6 groups of 5 animals each (n=5); Group 1: normal control, Group 2: ulcer rats received normal saline, Group 3: ulcer rats treated with P. halepensis, Group 4: ulcer rats were treated with zinc, Group 5: ulcer rats were treated with P. halepensis + zinc and Group 6 ulcer rats were treated with Ranitidine for 15 days. Stomach ulcer was induced by a single oral administration of indomethacin (30 mg/kg). Various biochimical, physiologic and histologic parameters were estimated. Obtained results show that the ulcer index, pH and total acidity level were significantly reduced (p<0.05) and Pepsin activity was significantly increased (p< 0.05) in ulcer induced rats pre-treated with extract of P. halepensis, zinc and ranitidine when compared with indomethacin treated rats. The MDA level was significantly decreased and GSH level was increased (p< 0.05) in rats treated with plant extract and zinc. Histopathology of gastric mucosa confirmed the gastro-protection by plant and zinc treatment. The study reveals anti-ulcer and antioxidant properties were observed in bark aqueous extract of P. halepensis groups with a benefic effect of zinc to reduce oxidative stress and gastric ulcer induced in the rat.
Highlights
The stomach is a remarkable organ as it secretes digestive juices that can digest the various foods we eat, but seldom digests it-self
This study was carried out to investigate the gastro-protective effect of aqueous extract of P. halepensis barks and Zinc against experimental gastric ulcer induced by indomethacin in rats
The results show that treatment with P. halepensis, zinc and ranitidine decrease significantly (p
Summary
The stomach is a remarkable organ as it secretes digestive juices that can digest the various foods we eat, but seldom digests it-self. Oxidative damage is responsible for gastric mucosal injuries, including ulceration, erosion and hemorrhage. It increases the formation of superoxide radicals and hydrogen peroxide (H2O2), lipid peroxidation and protein oxidation, which can directly promote damage of DNA, membrane lipids, cellular proteins and organelles [3]. Natural products have a wide range of diversity of multidimensional chemical structures; in the meantime, the utility of natural products as biological function modifiers has won considerable attention. They have been successfully employed in the discovery of new drugs and have exerted a far-reaching impact on chemicobiology [7]. This study was carried out to investigate the gastro-protective effect of aqueous extract of P. halepensis barks and Zinc against experimental gastric ulcer induced by indomethacin in rats
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