Abstract
This study aimed to investigate the protective effect of Xinmailong injection on rats with myocardial infarction. Thirty-six rats were induced myocardial infarction by operation, and six underwent sham operation. The myocardial infarction rats were randomly divided into three groups, 12 in each, and administered intraperitoneal injection of Xinmailong 5 mg/(kg·d), sodium creatine phosphate 80 mg/(kg·d), or normal saline as control respectively for 14 days. When the treatments were completed, the hemodynamic parameters of the rats were observed, and blood samples were taken to examine blood routine, blood coagulation index, liver and kidney function, inflammatory index, myocardial marker, thrombo-elastography, and other indicators. The morphology of cardiomyocytes was observed through light microscopy, and the microstructure of the myocardial cells was observed under electron microscope. No significant difference was found in blood routine, liver and kidney function, and blood coagulation index between the Xinmailong and sodium creatine phosphate groups compared with the saline control group. However, the inflammatory index and levels of myocardial markers were significantly decreased, and cardiac function was significantly improved. In terms of the morphology of myocardial cells, the Xinmailong group was similar to the sodium creatine phosphate group, the myocardial cell membrane was protected, and myocardial cell damage was reduced. In conclusion, Xinmailong is safe and had anti-inflammatory, heart-improving, and myocardial-protective effects. Its effectiveness is not inferior to that of sodium creatine phosphate.
Highlights
Acute myocardial infarction (AMI) refers to myocardial necrosis caused by acute and persistent ischemia and hypoxia in coronary arteries
During the course of the study, three rats died in both saline control and sodium creatine phosphate groups, while two died in the Xinmailong group
We found that the kinetics (K) value was significantly decreased and the angle value was significantly increased in the control, sodium creatine phosphate, and Xinmailong groups compared with the sham operation group
Summary
Acute myocardial infarction (AMI) refers to myocardial necrosis caused by acute and persistent ischemia and hypoxia in coronary arteries. It can be complicated with arrhythmia, shock, or heart failure (HF) and often life-threatening. The AMI morbidity continues to increase every year. It is one of the leading causes of death in patients with cardiovascular diseases (Fox, 2000; Reynolds et al, 2017; Liu et al, 2019; Han et al, 2020). When AMI is complicated with HF, the inflammatory reaction following myocardial ischemia is more serious. Improving heart function, especially through early correction of abnormal cardiac function, is important to improve patients’
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