Protective effect of tnf-α and il-1β inhibitor fr167653 on ischemia-reperfusion injury in rat small intestinal transplantation

Abstract

RECENTLY, it has been demonstrated that the proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-1 may play an important role in ischemia-reperfusion (I-R) injury in several organs such as the liver, lung, kidney, heart, and small intestine, both in nontransplant and in transplant experimental models,1,2 as well as in clinical transplant cases.3 A newly developed agent, {type:entrez-nucleotide,attrs:{text:FR167653,term_id:258093044,term_text:FR167653}}FR167653 (FR), has recently been shown to have potent specific inhibitory effects on TNF-α and IL-1β activity in vitro and in vivo. In this study, we investigated the protective effect of FR on I-R injury of intestinal grafts as well as remote organs such as liver, kidney, and lung in a rat transplantation model.