Abstract
Tet is a type of alkaloid extracted from Stephania tetrandra, and it has recently been demonstrated that Tet can protect against inflammation and free radical injury and inhibit the release of inflammatory mediators. The present study was designed to observe the protective effect of Tet on sodium taurocholate-induced severe acute pancreatitis (SAP). The rat model of SAP was induced by retrograde bile duct injection of sodium taurocholate and then treated with Verapamil and Tet. The results showed that Tet can reduce NF-κB activation in pancreas issue, inhibit the SAP cascade, and improve SAP through inducing pancreas acinar cell apoptosis and stabilizing intracellular calcium in the pancreas, thus mitigating the damage to the pancreas. Our study revealed that Tet may reduce systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS) to protect against damage, and these roles may be mediated through the NF-κB pathway to improve the proinflammatory/anti-inflammatory imbalance.
Highlights
Acute pancreatitis (AP) is an acute abdominal condition
Severe acute pancreatitis (SAP) is often accompanied by systemic inflammatory response syndrome (SIRS), acute respiratory distress syndrome (ARDS), acute lung injury (ALI), acute renal insufficiency, and hepatic impairment
(2) Immunosuppressive effects: Tet can inhibit IκB degradation, inhibiting NF-κB transporter activation and the expression of NF-κB-dependent genes. It can thereby significantly reduce the generation of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)
Summary
Acute pancreatitis (AP) is an acute abdominal condition. There are two types of AP, mild and severe. Mild AP, which accounts for 80% of the cases of AP, is self-limiting. Approximately 20% of the cases of AP are severe [1]. Severe acute pancreatitis (SAP) is a life-threatening condition with a high mortality rate that progresses rapidly and is associated with many complications. The pathological features of SAP include extensive pancreatic hemorrhage and large areas of necrotic tissue [2]. SAP is often accompanied by systemic inflammatory response syndrome (SIRS), acute respiratory distress syndrome (ARDS), acute lung injury (ALI), acute renal insufficiency, and hepatic impairment. The mortality rate for SAP is as high as 20% to 30% [4]
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