Abstract
Aims: To study the protective effect of hydroalcoholic bark extract of Terminalia arjuna against DBTC induced pancreatic cancer in male wistar rats.
 Study design: Healthy male Wistar Albino rats weighing 150-200 g were segregated into four groups (n=6). Group I was considered as normal control, received normal saline (0.9%w/v, 1 ml/kg body weight, orally). Group II rats were treated with DBTC (6 mg/kg body weight, i.p.) which served as negative control. Group III and IV received Terminalia arjuna Linn bark hydroalcoholic extract at doses of 250 mg/kg body weight, per oral and 500 mg/kg body weight, per oral respectively.
 Place and Duration of Study: University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India, between May 2020 and July 2020.
 Methodology: The experimental animals were segregated into four groups of six rats each. According to acute toxicity data, 250 mg/kg as low dose and 500 mg/kg as high dose of the test compound have been chosen for administration. All the drugs were given for 28 consecutive days to all the respective groups with standard pellet diet and water ad libitum. The assessment of serum parameters such as α-Amylase, Lipase and blood glucose levels were carried out on 1st day, 14th day and 28th day to the respective groups.
 Results: Pretreated groups of Terminalia arjuna Linn bark hydroalcoholic extract (250 mg/kg and 500 mg/kg body weight, orally) showed significant (‘#’p<0.001) decrease in the levels of α-Amylase, Lipase and glucose in the blood when compared to DBTC (6 mg/kg body weight, i.p.) induced group which served as negative control.
 Conclusion: This study suggests that Terminalia arjuna may have a protective role against DBTC induced pancreatic cancer in male wistar rats and further investigation may be required to confirm its therapeutic potentials clinically.
Highlights
Cancer is a major public health issue worldwide and is the second leading cause of death in the United States [1]
[21] In the current investigation, acute toxicity study reported that hydroalcoholic bark extract of Terminalia arjunahas LD50>2000 mg/kg body weight
The hydroalcoholic extract of Terminalia arjuna bark extract was assessed for effect on serum α-Amylase, Lipase and glucose to understand its protective role in DBTC induced pancreatic cancer in male wistar rats
Summary
Cancer is a major public health issue worldwide and is the second leading cause of death in the United States [1]. Pancreatic cancer is one of the most lethal of known cancers and the only treatment is surgery. It is the 7th most common cause of cancer related deaths in western countries. Terminalia arjuna is a sacred medicinal plant commonly called as Thella Maddi belongs to Combretaceae family. It contains pale yellow flowers, grey and soft bark with abundance of phytochemicals such as hydrolysable tannins, glycosides, flavonoids and phenolics [9] which are used to treat plethora of diseases. Pharmacological investigations of Terminalia arjuna have been reported for the treatment of endothelial dysfunction, [10] antioxidant property, nitric oxide inhibitory activity, [11] anti-hypertensive property, [12] improves cardio-vascular endurance, [13] antidiabetic property, [14] and antifungal property. [15] Research evidences revealed that the hydroalcoholic extract of Terminalia arjuna have anti-colitis activity [16] and improves proinflammatory cytokines, cardiac and apoptotic indicators in myocardial infarction. [17] Terminalia arjuna has been less explored for its varying pharmacological properties, an attempt has been made to assess its anticancer activity in DBTC induced pancreatic cancer in male Wistar albino rats
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
