Abstract
ABSTRACT Objectives：Socheongryong-Tang (小靑龍湯, SCRT) has been widely used to treat r espiratory disease. In this study, we investigated the protective effects of SCRT on hydrogen peroxide-induced hepatotoxicity.Methods：In the mouse primary liver cells, SCRT was pretreated for 1 h, and 1 mM H 2 O 2 was treated to mouse primary liver cells. Cell viability was analyzed by using 3- 4, 5-Dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay. Also, the activity of AST, ALT and LDH wer e measured for the evaluation the protective effect of SCRT on H 2 O 2 -induced hepatotoxicity. Intracellular ROS level was analyzed by FACS.Results：SCRT pretreatment decreased H 2 O 2 -induced hepatotoxicity and intracellular ROS production. Pretreatment of SCRT significantly reduced the cytotoxic effect induced by H 2 O 2 , associated with reducing DNA fragmentation and AST, ALT, LDH activities.Conclusions：These results suggest that SCRT has protective effect against H 2 O 2 -induced hepatotoxicity.Key words：Socheongryong-Tang, H
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