Abstract
Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gastric ulcer. The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix Aspersa Muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of ethanol intragastric administration which has been widely used to test the drugs efficacies and to explore the underlying mechanism for gastric ulcer development. The intragastric ethanol administration causes several mucosal damages and an induction of a severe inflammatory response. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on mucus content, oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer.
Highlights
Gastric ulcer or peptic ulcer is a common disease worldwide
A fundamental step in involved in the complex event of gastric ulcer formation is the infiltration of neutrophil, in particular activated neutrophil are responsible for increase in oxidative stress and inflammatory r esponse[29,30]
According to the results mentioned so far we have found that the treatment with Snail Secretion Filtrate (SSF) at doses of 7.5 ml/kg and 15 ml/kg showed a significant protective effect on oxidative stress induced by EtOH, and in particular SSF treatment significantly prevent the increase in MDA levels, and the depletion in CAT and SOD levels
Summary
Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer. The gastric ulcer or peptic ulcer is a disease that affect a significative number of people worldwide It develops when there is an imbalance between the protective and aggressive factors at the luminal surface of epithelial cells. The effectiveness of Helix Aspersa extract has been demonstrated as a safe and effective alternative treatment in open wound management of partial thickness burns in adults, favoring its re-epithelialization[9] These important properties of snail slime and in particular pro-epithelizing and wound repair are due to the peculiar chemical composition of this c ompound[12]. Evaluating the effect on gastric mucosal, oxidative stress and inflammatory response
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