Abstract
A photostabilization strategy is an important aspect of quality assurance for photosensitive compounds. This study focused on the photoprotective effects of selected antioxidants including the effect of L-ascorbic acid (AA) on naproxen (NX) photodegradation in aqueous media. NX degradation during ultraviolet light (UV) irradiation and the protective effects of selected antioxidants were monitored by high-performance liquid chromatography (HPLC). The addition of AA induced the suppression of NX photodegradation, although the protective effect disappeared after AA was degraded completely. The results of the evaluations on the photoprotective effects on NX photodegradation and antioxidative activities of AA and other antioxidants showed that the protective effects of antioxidants are dependent on reducing power and photostability under UV irradiation. In this experiment, quercetin (QU) is the most effective antioxidant on account of the residual rate of QU after UV irradiation and the antioxidative activity in the potential antioxidant (PAO) test was significantly higher compared to other antioxidants following the higher protective effect on NX photodegradation.
Highlights
It is well known that exposure to ultraviolet light (UV) irradiation, which is present in sunlight, can induce changes in the properties of chemical compounds
The photosensitivity of chemical compounds is an important factor for the determination of photosensitivity of chemical compounds is an important factorphotostabilization for the determination of their their The nature, which may be influenced by UV irradiation
The antioxidative property of AA is derived from the release of hydrogen from the 2,3-enediol moiety following conversion to dehydroascorbic acid, which has no antioxidative potency, and this reaction proceeded immediately at room temperature by the photoirradiation [23]. These findings show that an AA solution is unstable due to oxidation by the dissolved oxygen on UV irradiation
Summary
It is well known that exposure to ultraviolet light (UV) irradiation, which is present in sunlight, can induce changes in the properties of chemical compounds. Chemical compounds that tend to be affected by UV irradiation are called photosensitive compounds. Photosensitive compounds, including chemical UV filters and pharmaceuticals, are reported to be degraded or converted to products by UV irradiation [1,2,3,4,5]. It is reported that the biological effects of some pharmaceuticals are changed by UV irradiation [6,7,8] on account of their photoconversion to photoproducts. Various photochemical reactions may be induced by UV irradiation [9,10,11]. These reports indicate that the generation of various photoproducts is dependent on these chemical reactions. The photosensitivity of chemical compounds is a major determinant of their quality and quantity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
