Abstract
Objective To study the protective effect of saturated hydrogen saline against cerebral ischemia-reperfusion injury and the related mechanism.Methods Rat middle cerebral artery occlusion(MCAO) models were established by thread ligation of the middle cerebral artery.The rats were sacrificed 24 h later.The cerebral infarction volume was determined by TTC staining,the water content in brain tissue by dry-wet weight method,the degree of cerebral cells by Nissl staining,and the levels of IL-1β and TNF-α in the ischemic cerebral tissues by ELISA.Results Compared with control group,hydrogen saline decreased the brain water content and cerebral infarction volume,and increased the quantity of nissel's body in the cortex;meanwhile,it also significantly decreased the concentrations of IL-1β and TNF-α in brain tissue(P0.05).Conclusion Hydrogen saline can alleviate the cerebral ischemia-reperfusion injury,probably by inhibiting the inflammation response.
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