Abstract
This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7days. The rutin-100 group received 100mg/kg/b.w. rutin for 7days. Mercuric chloride (HgCl2 ) group received 1.23mg/kg/b.w. of HgCl2 for 7days. Mercury chloride+rutin-50 group received 50mg/kg/b.w. rutin and HgCl2 1.23mg/kg/b.w. for 7days. HgCl2 +rutin-100 group received 100mg/kg/b.w. rutin and HgCl2 1.23mg/kg/b.w. for 7days. It was detected that HgCl2 treatment increased malondialdehyde (MDA) levels, tumour necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused by HgCl2 . In conclusion, rutin administration may treat HgCl2 toxicity in testes.
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