Abstract
Modulation of gap junctional coupling is known to influence arrhythmogenesis. In this study we examined the effect of rotigaptide, an antiarrhythmic peptide on acute ischaemia-induced ventricular arrhythmias in anaesthetised, open-chest dogs. Three doses of rotigaptide were administered (0.04; 0.2; and 1 μg/kg/min) in intracoronary infusion 10 min before and during 60 min of occlusion of the left anterior descending coronary artery. Control dogs were given saline throughout the occlusion. During the ischaemic period ventricular arrhythmias were evaluated and gap junction function was monitored by measuring electrical impedance.
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