Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits

Abstract

Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P 0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.