Abstract
Molecular construction of NADH-cytochrome b5 reductase inhibition by flavonoids and chemical basis of difference in inhibition potential: Molecular dynamics simulation studySharad Verma, Amit Singh, Abha Mishra
Highlights
Neuroinflammation is the immune response in the neuronal tissues of brain in which the resident immune cells–microglia—secretes pro-inflammatory factors on the activation of cytokines to scavenge the pathogenic infiltrators and minimize the damages (Jin-Tao et al, 2015)
This study reports protective effect of dietary quercetin against neuroinflammation-induced changes in mice triggered by weight drop injury model
These findings suggest that dietary quercetin has potential benefits in mitigating neuroinflammation-mediated oxidative stress and behavioral and histological alterations
Summary
Neuroinflammation is the immune response in the neuronal tissues of brain in which the resident immune cells–microglia—secretes pro-inflammatory factors on the activation of cytokines to scavenge the pathogenic infiltrators and minimize the damages (Jin-Tao et al, 2015). Cytokines and chemokines play a role in mediating the inflammation of the brain tissue (Geeta et al, 2013) This resident immune cells—microglia—sometimes go uncontrolled and lead to prolonged activation in the course of time, thereby releasing enormous amount of harmful neurotoxic compounds. The force in WDM quickly accelerates the head into a supporting foam block, resulting in diffuse brain injury without skull fracture. Primary characterization of this model revealed bilateral injury to neurons in the cerebral cortex in the brain (Thomas et al, 2004). We developed a model of TBI in mice using a closed-head, weight-drop technique, which characteristically shows significant disruption to the blood–brain barrier, local and systemic inflammation, and functional deficits in behavioral, stress markers, and histological alterations. The present study evaluates the protective effects of quercetin on neuropathological injuries of TBI in mice model which almost all equivalent to natural head injuries
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