Abstract
This study examined the protective effects of quercetin on chronic ethanol-induced liver injury. Rats were treated with ethanol at a dose of 4 g/100 g/day for 90 days. After ethanol intoxication, levels of serum amino transferases were significantly elevated. Decreased activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase was also observed on ethanol administration. Increased amounts of lipid peroxidation products viz. hydroperoxides, conjugated dienes and malodialdehyde were observed on ethanol intoxication. Ethanol administration resulted in significant decrease in liver glutathione content. After 90 days, the control animals were divided into two groups, the control group and the control+quercetin group. Ethanol-treated group was divided into two groups, abstention group and quercetin-supplemented group. After 30 days, the animals were sacrificed and various biochemical parameters were analyzed. The changes in enzyme activities as well as levels of lipid peroxidation products were reversed to a certain extent by quercetin. Quercetin supplementation resulted in increase of glutathione content to a significant level compared to normal abstention group. Quercetin supplemented group showed a faster recovery than abstention group. This shows the protective effect of quercetin against chronic ethanol induced hepatotoxicity. Histopathological study is also in line with these results.
Highlights
This study examined the protective effects of quercetin on chronic ethanol-induced liver injury
Supplementation of quercetin in group II B further reduced the activities of these enzymes
The activity of glutathione peroxidase was reduced in ethanol-treated group (Table 2)
Summary
Protective effect of Quercetin in the Regression of Ethanol-Induced Hepatotoxicity. This study examined the protective effects of quercetin on chronic ethanol-induced liver injury. Quercetin supplementation resulted in increase of glutathione content to a significant level compared to normal abstention group. Quercetin supplemented group showed a faster recovery than abstention group This shows the protective effect of quercetin against chronic ethanol induced hepatotoxicity. Flavanoids are a group of naturally occuring compounds widely distributed as secondary metabolites in plant kingdom One of these ßavanoids, quercetin (3,5,7,3,4-pentahydroxy ßavon), is one of the most prominent dietary antioxidant. One of the most important problems faced by those who have stopped alcohol consumption after chronic intake, is the recovery of damaged hepatocytes to normal level. We have studied the effect of quercetin in the regression of ethanol-induced hepatotoxicity
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