Abstract
Qiliqiangxin capsule (QL) was developed under the guidance of TCM theory of collateral disease and had been shown to be effective and safe for the treatment of heart failure. The present study explored the role of and mechanism by which the herbal compounds QL act on energy metabolism, in vivo, in pressure overload heart failure. SD rats received ascending aorta constriction (TAC) to establish a model of myocardial hypertrophy. The animals were treated orally for a period of six weeks. QL significantly inhibited cardiac hypertrophy due to ascending aortic constriction and improved hemodynamics. This effect was linked to the expression levels of the signaling factors in connection with upregulated energy and the regulation of glucose and lipid substrate metabolism and with a decrease in metabolic intermediate products and the protection of mitochondrial function. It is concluded that QL may regulate the glycolipid substrate metabolism by activating AMPK/PGC-1α axis and reduce the accumulation of free fatty acids and lactic acid, to protect cardiac myocytes and mitochondrial function.
Highlights
Hypertension is one of the most common cardiovascular diseases and a major cause of heart failure
Qiliqiangxin capsule (QL) capsules are traditional Chinese medicine (TCM) formula, which was developed according to TCM theory
Pharmacological studies have found that QL contains a number of active substances such as ginseng saponin, astragalus saponin, flavonoid, cardenolide, and phenolic acid
Summary
Hypertension is one of the most common cardiovascular diseases and a major cause of heart failure. Increase of pressure load due to long-term hypertension will cause myocardial fibrosis and left ventricular compensatory hypertrophy. Qiliqiangxin capsule (QL) was developed under the guidance of TCM theory of collateral disease [3]. It is a drug of Chinese medicine for the treatment of heart failure, registered in the Chinese State Food and Drug Administration (SFDA) in 1996, and had been used in clinical practice for more than a decade. Previous studies have shown that some of the plants in the QL formula impacted energy metabolism. Astragalus has been shown to inhibit myocardial hypertrophy and improve energy metabolism by increasing the membrane potential [6]. Previous studies have shown that QL interfered with the Evidence-Based Complementary and Alternative Medicine
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