Abstract
Both thyroid hormones and PPARγ agonists are suggested to have some effects on the reproductive system. Here, the effects of pioglitazone on testicular tissue damages in propylthiouracil (PTU)-induced hypothyroidism were evaluated. Pioglitazone increased the number of sperm and volume and weight of the testis while, decreased TUNEL positive cells of 0.5% PTU-treated rats. Pioglitazone also improved thiol, superoxide dismutase, and catalase while decreased malondialdehude (MDA) in testicular tissue. Thus, pioglitazone appears to provide a protective effect against on testicular damages induced by PTU.
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