Protective Effect of Potentilla glabra in UVB-Induced Photoaging Process.

Long You,Mi-Yeon Kim,Jae Youl Cho

doi:10.3390/molecules26175408

Long You, Mi-Yeon Kim + Show 1 more

Open Access

https://doi.org/10.3390/molecules26175408

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Abstract

Maintaining skin homeostasis is one of the most important factors for skin health. UVB-induced skin photoaging is a difficult problem that has negative impacts on skin homeostasis. So far, a number of compounds have been discovered that improve human skin barrier function and hydration, and are thought to be effective ways to protect skin homeostasis. Potentilla glabra var. mandshurica (Maxim.) Hand.-Mazz. Ethanol Extract (Pg-EE) is a compound that has noteworthy anti-inflammatory properties. However, its skin-protective effects are poorly understood. Therefore, we evaluated the capacity of Pg-EE to strengthen the skin barrier and improve skin hydration. Pg-EE can enhance the expression of filaggrin (FLG), transglutaminase (TGM)-1, hyaluronic acid synthase (HAS)-1, and HAS-2 in human keratinocytes. Moreover, Pg-EE down-regulated the expression of pro-inflammatory cytokines and up-regulated the production of FLG, HAS-1, and HAS-2 suppressed by UVB through inhibition of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) pathways. Given the above, since Pg-EE can improve skin barrier, hydration and reduce the UVB-induced inflammation on skin, it could therefore be a valuable natural ingredient for cosmetics or pharmaceuticals to treat skin disorders.

Highlights

We examine the characteristics of Pg-EE in keratinocytes, which are a type of skin cell, under UVB irradiation
Before evaluating the characteristics of Pg-EE, we tested the viability of HaCaT cells
We evaluated the effects of Pg-EE on skin protection and anti-inflammation under UVB irradiation

Summary

Introduction

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Skin is the largest organ in our body and has various distinct and complex functions. It is comprised of three distinct layers: epidermis, dermis and subcutis [1]. The epidermis is the outermost layer of the skin that acts as a barrier against damage from the environment, which includes pressure, micro-organisms, and radiation [2,3,4]. Keratinocytes make up nearly 95% of the epidermis. The stratum corneum (SC) is the outermost layer of the epidermis and has a pivotal role in maintaining skin barrier integrity and skin elasticity [5]

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