Protective Effect of Phenolic Extract of Urtica dioica leaves against Carbon Tetra-Chloride Induced Hepatotoxicity in Male Rats

Abstract

The present study concluded phenolic extract of Urtica dioica leaves the protecting effect against CCL4 induced hepatotoxicity. The present study refered to a significant increase (P=0.05) in serum levels of liver enzymes (ALP, ALT, AST), and bilirubin level in carbon tetrachloride-induced groups as compared with control group. The current study revealed the occurrence of a significant decrease (P=0.05) in the level of liver enzymes When administered by phenolic extract for (two and three months) compared with carbon tetrachloride group. Highly significant (P=0.05) with the concentration of the (500mg/kg) for phenolic extract, and no significant observed between phenolic extract for (two and three months) and before and after induced by the carbon tetrachloride. Histological section of liver male rat induced by carbon tetrachloride for two months showed inflammation and degeneration of hepatocytes, however, the histological section is shown chronic inflammation, severe congestion and haemorrhage, accumulation of fat, degeneration and necrosis, severe degeneration of hepatocytes, and appearance fibroblast for three months. The histopathological changes of liver in male rats treated with both doses (250 and 500 mg/kg) of a phenolic extract of Urtica dioica leaves showed the normal architecture of hepatocytes.