Abstract
BackgroundPalmijihwanghwan (PJH) is a traditional medicine and eight constituents derived from PJH possess anti-inflammatory activities. However, the scientific evidence for its potential as a therapeutic agent for inflammatory lung disease has not yet been studied. In this study, we examined the protective effect of PJH in a mouse model of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke (CS) with lipopolysaccharide (LPS).MethodsMice received CS exposure for 8 weeks and intranasal instillation of LPS on weeks 1, 3, 5 and 7. PJH (100 and 200 mg/kg) was administrated daily 1 h before CS treatment for the last 4 weeks.ResultsCompared with CS plus LPS-exposed mice, mice in the PJH-treated group showed significantly decreased inflammatory cells count and reduced inflammatory cytokines including interleukin-1 beta (IL-1β), IL-6 and tumor necrosis factor alpha (TNF-α) levels in broncho-alveolar lavage fluid (BALF) and lung tissue. PJH also suppressed the phosphorylation of nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinase1/2 (ERK1/2) caused by CS plus LPS exposure. Furthermore, CS plus LPS induced increases in matrix metallopeptidase (MMP)-7, MMP-9, and transforming growth factor-β (TGF-β) expression and collagen deposition that were inhibited in PJH-treated mice.ConclusionsThis study demonstrates that PJH prevents respiratory inflammation and airway remodeling caused by CS with LPS exposure suggesting potential therapy for the treatment of COPD.
Highlights
Palmijihwanghwan (PJH) is a traditional medicine and eight constituents derived from PJH possess antiinflammatory activities
cigarette smoke (CS) is metabolized to numerous toxic chemical substances that generate reactive oxygen species (ROS), which play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD)
UPLC‐DAD‐MS/MS analysis of PJH To determine the phytochemicals in PJH, consisting of the eight herbal medicines, Dioscorea batatas, Paeonia suffruticosa, Rehmannia glutinosa, Cornus officinalis, Aconitum carmichaelii, Cinnamomum cassia, Alisma orientale and Poria cocos [33], we performed
Summary
Palmijihwanghwan (PJH) is a traditional medicine and eight constituents derived from PJH possess antiinflammatory activities. The scientific evidence for its potential as a therapeutic agent for inflammatory lung disease has not yet been studied. We examined the protective effect of PJH in a mouse model of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke (CS) with lipopolysaccharide (LPS). Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease associated with persistent respiratory symptoms such as dyspnea, sputum overproduction, and cough [1]. Adverse drug reactions associated with several classes of drugs, including corticosteroids and PDE4 inhibitors, especially theophylline, have been reported, highlighting the need for alternative therapies, in particular, herbal products [9]. Herbal therapies for COPD are intended to mitigate symptoms, prevent recurrence, reduce the risk of comorbidities and improve the quality of life
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