Abstract
Female BRCA1/BRCA2 mutation carriers are known to have an elevated risk for developing ovarian, fallopian tube, peritoneal, and breast carcinoma. Ablative surgery with bilateral salpingo-oophorectomy (BSO) has been shown to significantly reduce this risk to a greater degree than surveillance or chemoprevention alone. However, the impact of surgically induced menopause on cancer risk must be balanced against overall health implications and quality of life. To gain greater insight into the holistic effect of BSO, …
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