Abstract
Ultraviolet (UV) irradiation damages skin and produces symptoms of photoaging, such as thickening, rough texture, wrinkles, and pigmentation. However, the cellular and molecular mechanisms underlying photoaging induced by chronic UV irradiation are not yet fully understood. Matrix metalloproteinases (MMPs) have been reported to be involved in the response to UV irradiation. In this study, we examined the effects of the sunscreen agent Octylmethoxycinnamate (OMC) on photoaging of the skin induced by chronic UV exposure in hairless albino Crl:SKH1-Hrhr (SKH-1) mice. We demonstrated that the expression of MMPs was elevated by UV irradiation, whereas the topical application of OMC inhibited the upregulation of MMPs. Furthermore, UV-induced wrinkle formation was decreased by OMC treatment. These results suggest that OMC is a potential agent for the prevention and treatment of skin photoaging.
Highlights
The physical symptoms of skin aging induced by ultraviolet (UV) irradiation in human skin include thickening, rough texture, coarse wrinkles, and mottled pigmentation [1]
Akin photoaging is caused by chronic UV exposure, which results in a change in the dermal level of collagen and elastin
UV irradiation interferes with the preservation of the extracellular matrix and participates significantly in the development of premature skin aging [7,8]
Summary
The physical symptoms of skin aging induced by ultraviolet (UV) irradiation in human skin include thickening, rough texture, coarse wrinkles, and mottled pigmentation [1]. The disorganization, fragmentation, and dispersion of collagen bundles are prominent features in photodamaged human skin [2]. Various cells, such as keratinocytes, fibroblasts, and inflammatory cells, produce matrix metalloproteinases (MMPs) under UV irradiation. UV exposure induced an increase in the expression of MMP-1, -3, and -9 in the normal human epidermis and MMP-13 in human dermal fibroblasts [5] These results indicate that the repeated degradation of collagen by UV-induced MMPs may lead to its deficiency in photodamaged skin. These properties make MMPs an attractive target for the development of anti-photoaging agents. In the present study, we evaluated the protective effects of OMC against UV-induced photoaging in SKH-1 hairless mice, focusing on the regulation of MMPs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
