Abstract
Protective Effect of Nigella Sativa (Black Caraway (Oil on Oral Dichlorvos Induced Hematological, Renal and Nonspecific Immune System Toxicity in Wistar Rats
Highlights
Harmful chemicals in the environment and their burden on health have become an issue of great importance in recent decades [1], causing toxicity to a variety of biota and human life [2].Organophosphates (OPs) are one of the most dangerous chemicals used in agriculture and household, and are highly toxic to liver and muscles, as well as, nervous, immune, urinary, reproductive and hematological systems [3,4,5].A commonly used OP, dichlorvos or 2, 2dichlorovinyl dimethyl phosphate (DDVP), is extensively used for pest and insect control [6], and despite the reported toxicity, it is a major constituent of most of the insecticides used in the developing world [7]
This study investigated the antidotal efficacy of N. sativa oil in mitigating dichlorvos induced hematological, immunological and renal damage in Wistar rats
DDVP resulted in reduction in the mean cell volume (MCV), mean cell hemoglobin (MCH), and increased mean cell hemoglobin concentration (MCHC), not statistically significant
Summary
Harmful chemicals in the environment and their burden on health have become an issue of great importance in recent decades [1], causing toxicity to a variety of biota and human life [2].Organophosphates (OPs) are one of the most dangerous chemicals used in agriculture and household, and are highly toxic to liver and muscles, as well as, nervous, immune, urinary, reproductive and hematological systems [3,4,5].A commonly used OP, dichlorvos or 2, 2dichlorovinyl dimethyl phosphate (DDVP), is extensively used for pest and insect control [6], and despite the reported toxicity, it is a major constituent of most of the insecticides used in the developing world [7]. We investigated the effects of continuous exposure to dichlorvos (DDVP) on kidney function and hematological parameters, and the possible antidote activity of Nigella sativa oil (NSO). Results: Rat exposed to DDVP showed red blood cell count, hemoglobin, packed cell volume, albumin, and total protein levels was reduced from control, while white blood cell count and urea significantly increased as compared to controls, the change in K+ level was not significant. NSO maintained optimal levels of red blood cell count, hemoglobin, packed cell volume, albumin, white blood cell count, and urea, indicative of its protective effect against hemo-, immuno- and nephrotoxicity of DDVP. Conclusion: N. sativa (Black Caraway) oil might be a potential antidote in hematotoxicity, immunosuppression and renal dysfunction in organophosphate poisoning, especially dichlorvos.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
