Abstract

Abstract Atopic dermatitis (AD) is a serious inflammatory condition associated with severe itching and persistent eczematous lesion. Therefore, the present study was intended to scrutinize the beneficial effect of Luteolin (LT) on the atopic dermatitis murine model. The effect of LT was investigated on the various parameters, such as oxidative stress and inflammation after induction of AD. The serum level of IgE, and cells of the WBC family (neutrophils, basophils, eosinophils, monocytes, lymphocytes, and total WBC) and histopathological analysis of skin tissue were also examined to confirm the effect of LT. Results of the study suggested that LT significantly inhibited the elevated IgE level together with improvement in injured skin tissue architecture. It also reduces oxidative stress (MDA, SOD, and GSH) and inflammation (IL-1β, IL-6, TNF-α, IFN-γ, IL-4, and IL-17A) as evidenced by ELISA analysis. The level of examined WBC family cells was found reduced significantly as compared to the AD model group. In western blot analysis, LT showed significant down-regulation of NF-ĸB and TLR-4. Collectively, our results suggest that LT can effectively reverse the effect of atopic dermatitis via improving immunological response.

Highlights

  • Atopic dermatitis (AD) is a serious inflammatory condition associated with severe itching and persistent eczematous lesion

  • In the present study, for the first time, we have demonstrated the protective effect of LT in atopic dermatitis mediated via IgE and NF-ĸB

  • It has been found that LT causes a significant reduction in an elevated level of IgE suggesting its protective effect against LT via reducing IgE-mediated immune response (Kawakami et al 2009; Liu et al 2011; Horimukai et al 2014)

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Summary

Introduction

Atopic dermatitis (AD) is a serious inflammatory condition associated with severe itching and persistent eczematous lesion. Newer agents or therapies are needed to treat AD in a much efficient way with fewer side-effect

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