Abstract
Introduction: The aim of the study was to evaluate the protective effect of Hedera helix (ivy) leaf extract on paracetamol-induced oxidative stress and renal toxicity in mouse model. Methods: Sixty male Swiss albino mice were randomly divided into six equal groups. Group A: as the control group, received NaCl 0.9%. Group B: received a single (i.p.) injection of paracetamol (600 mg/kg). Pretreatment groups: included T1 (50 mg/kg), T2 (100 mg/kg), T3 (200 mg/kg), and T4 (300 mg/kg) which were treated with ivy leaf extract in different doses. The mice were sacrificed under mild anesthesia and the blood samples were collected to titrate the levels of serum blood urea nitrogen (BUN), creatinine and, uric acid. Kidneys were removed for histopathological examination. Results: Paracetamol administration significantly increased the BUN, creatinine and uric acid levels (P < 0.05). Treatment with Ivy leaf extract resulted in a significant reduction in serum creatinine, uric acid and BUN concentrations in comparison with the paracetamol group. Ivy leaf extract treatment similarly reduced histological alteration induced by paracetamol. Conclusion: This study can be used as prove of reading that ivy leaf extract might be used to prevent renal damage induced by paracetamol.
Highlights
The aim of the study was to evaluate the protective effect of Hedera helix leaf extract on paracetamol-induced oxidative stress and renal toxicity in mouse model
On the day 9, the mice were killed under mild anesthesia 24 hours after the paracetamol administration, the blood samples were collected from different groups of mice to titrate the levels of serum blood urea nitrogen (BUN), creatinine and uric acid
The mechanism of acetaminophen-induced nephrotoxicity and hepatotoxicity has been reported by other investigators and showed that paracetamol causes oxidative stress and renal toxicity when used at high doses [21,22,23,24,25,26]
Summary
The aim of the study was to evaluate the protective effect of Hedera helix (ivy) leaf extract on paracetamol-induced oxidative stress and renal toxicity in mouse model. Treatment with Ivy leaf extract resulted in a significant reduction in serum creatinine, uric acid and BUN concentrations in comparison with the paracetamol group. Conclusion: This study can be used as prove of reading that ivy leaf extract might be used to prevent renal damage induced by paracetamol. Known as Ivy is an evergreen plant which belongs to Araliaceous family with small, heartshaped leaves. It is common in most parts of the world in East Asia, India, and America [4,5]. The ivy leaf extracts is used as anti-inflammatory, anti-cough, anti-neurologic pain, anti-rheumatism, antifungal, antiworm, anti-spasm, and anti-asthma [4,6]
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