Abstract
Hypericum triquetrifolium is an herbaceous perennial plant, numerous of the bioactive compound are present in it that is responsible for several biological functions. Aim of this research the protective effect of aqueous extract of Hypericum triquetrifolium on some biochemical parameters and histopathological study in hyperlipidemic male rats. Thirty-six male albino rats were divided into six groups, control group (fed with standard pellet), hyperlipidemia group , three ,four and five groups hyperlipidemic rats treated with aqueous extract of Hypericum triquetrifolium in different dosage (1000,2000,3000) mg/kg body weight, respectively, and last group hyperlipidemic rats treated with rosuvastatin drug 10 mg/kg for 60 days . The results showed that the body weight, serum cholesterol, triglyceride, low-density lipoprotein, very low-density lipoprotein, cholesterol/high-density lipoprotein ratio, and hepatic enzymes increased significantly (p˂0.05) in hyperlipidemia group when compared with control group, but Hypericum triquetrifolium have ability to reduction the level of body weight, serum cholesterol, triglyceride, low-density lipoprotein, very low-density lipoprotein, cholesterol/high-density lipoprotein ratio, as well as the low dose of H. triquetrifolium nonsignificantly (p>0.05), prevent to increase liver enzymes, conversely the level of liver enzymes in rosuvastatin group treatment increased when compared with other treated and untreated groups. Noticeable damage of histology in testis showed degeneration in the germinal layer and fat change in liver of hyperlipidemia and rosuvastatin group, the low dose of H. triquetrifolium has beneficial effect on sperm parameters and histology of testis and liver. The quantity of aqueous extract of Hypericum triquetrifolium and antioxidant power of this plant have an essential role in their activity. Hypericum triquetrifolium .
Highlights
Hyperlipidemia is a metabolic disorder considered that the proportion of total cholesterol, triglyceride, and low-density lipoprotein in bloodstream are increased
The features of familial hyperlipidemia are triggered by particular genetic abnormalities such as familial hypercholesteremic by mutating genes that encoding low-density lipoprotein (LDL) receptor in both hepatic and extra hepatic tissues which is due to an increase in the level of plasma LDL-C and elevated risk to heart disease [2]
The group of Rats that received rosuvastatin showed decreased the rate of TC, T.G, LDL, very-low-density lipoprotein (VLDL), and TC/high-density lipoprotein (HDL) ratio significantly (p
Summary
Hyperlipidemia is a metabolic disorder considered that the proportion of total cholesterol, triglyceride, and low-density lipoprotein in bloodstream are increased. The acquired hyperlipidemia is not inherited, mainly defect in lipoprotein lipase (LPL) activity via many diseases such as diabetes, hyperthyroidism and some kinds of liver disease that cause reduction excretion cholesterol to bile [3]. Many factors are affecting sperm production and maturation may be the environment, genetic or combine both, drugs can influence negatively on infertility, these effects might include incorporating spermatogenesis impairment and change of epididymal development or other impact induce sexual dysfunction through different mechanisms, maybe by variation hormones or no hormonal mechanism [12]. The purpose of this research to evaluate the effect of Hypericum triquetrifolium on the hyperlipidemic male albino rat to treat hyperlipidemia and compared with lipid-lowering drug rosuvastatin and influence on the male reproductive system
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